发明名称 |
VACCINES CONTAINING NON-IONIC SURFACTANT VESICLES |
摘要 |
<p>PCT No. PCT/GB93/00716 Sec. 371 Date Jan. 5, 1995 Sec. 102(e) Date Jan. 5, 1995 PCT Filed Apr. 6, 1993 PCT Pub. No. WO93/19781 PCT Pub. Date Oct. 14, 1993Non-ionic surfactant vesicles (NSIV) with entrapped antigen act as potent immunological adjuvants and can produce antibody titers of the same order of magnitude as those using Freund's Complete Adjuvant. The invention provides vaccines comprising such vesicles. Preferably non-ionic surfactants are glycerol esters particularly 1-monopalmitoyl glycerol. The vesicles may be administered by injection or via the mucosal route, oral administration being preferred.</p> |
申请公布号 |
EP0634937(B1) |
申请公布日期 |
1997.09.17 |
申请号 |
EP19930908000 |
申请日期 |
1993.04.06 |
申请人 |
PROTEUS MOLECULAR DESIGN LIMITED |
发明人 |
ALEXANDER, JAMES;BREWER, JAMES MACDONALD |
分类号 |
A61K9/08;A61K9/00;A61K9/127;A61K39/00;A61K39/39;C07K7/23;C07K14/12;C07K14/45;(IPC1-7):A61K39/39;A61K39/002;C07K7/06 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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