The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.
申请公布号
CA2244848(A1)
申请公布日期
1997.08.14
申请号
CA19972244848
申请日期
1997.02.07
申请人
ELI LILLY AND COMPANY;ELI LILLY AND COMPANY
发明人
COLACINO, JOSEPH MATTHEW;TANG, JOSEPH CHIOU-CHUNG;HORNBACK, WILLIAM JOSEPH;HATCH, STEVEN DUANE;MUNROE, JOHN EDWIN;MUESING, MARK AYER;STASCHKE, KIRK ALAN