发明名称 |
POST SYNTHESIS CHEMICAL MODIFICATION OF PARTICLE REAGENTS |
摘要 |
A method is provided for enhancing the stability and increasing the activity of polymer particle reagents by incubating a polymer particle which has been covalently bound to a compound of biological interest, such as a drug, with a modifying agent that will place a negative charge on the surface of the polymer particle and reduce residual functional groups. The modifying agent is preferably an anionic nucleophile selected from the group consisting of beta - mercaptoacetic acid and the thiosulfates. |
申请公布号 |
EP0784795(A1) |
申请公布日期 |
1997.07.23 |
申请号 |
EP19960927297 |
申请日期 |
1996.08.02 |
申请人 |
DADE CHEMISTRY SYSTEMS INC. |
发明人 |
CHU, VICTOR, PICHAI;CRAIG, ALAN, ROBERT |
分类号 |
G01N33/53;G01N33/543;(IPC1-7):G01N33/543;G01N33/94;G01N33/546 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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