METHOD OF HYDROXYTETRACYCLINE PRODUCING

摘要

FIELD: biotechnology, antibiotics. SUBSTANCE: culture Str. rimosus is grown on nutrient medium of the following composition, weight %: corn flour 13-15; soybean flour 0.7-0.9; chalk 1.4-1.6; corn extract 2.8-3.2, and propinol "Б"-400 0.01-0.02. After 156 h cultivation activity of cultural fluid is 14000 U/ml, antibiotic output from cultural fluid is 39 billion U, efficiency is. After 206 h growth activity, output, efficiency are 18300 U/ml, 52 billion U and, respectively. EFFECT: increased yield of oxytetracycline.