发明名称 |
GAMMA-L-GLUTAMYL CONTAINING IMMUNOMODULATOR COMPOUNDS AND METHODS THEREWITH |
摘要 |
The new class of synthetic immunomodulatory molecules having a gamma -L-glutamyl- moiety at the amino terminus are provided as illustrated by Formula (1). In the Formula (1), the Greek symbols designate the noted carbon atoms, R is hydrogen, acyl or alkyl, and X is an aromatic or heterocyclic amino acid or its derivative. Included as members of the new class (in addition to Bestim, gamma -L-glutamyl-L-tryptophan) are those compounds where R = hydrogen and X = L-tryptophan, such as gamma -L-glutamyl-Nin-formyl-L-tryptophan, N-methyl- gamma -L-glutamyl-L-tryptophan, N-acetyl- gamma -L-glutamyl-L-tryptophan, and gamma -L-glutamyl- beta -thienyl-D-alanylamide. A preferred embodiment, termed "Bestin", has the chemical structure of gamma -L-glutamyl-L-tryptophan.
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申请公布号 |
WO9719691(A1) |
申请公布日期 |
1997.06.05 |
申请号 |
WO1996US17913 |
申请日期 |
1996.11.13 |
申请人 |
WEI, EDWARD, T. |
发明人 |
KOLOBOV, ALEXANDER A.;SIMBIRTSEV, ANDREY S.;KULIKOV, SERGEY V.;PRUSAKOV, ALEXEY N.;KALININA, NATALIA M.;PIGAREVA, NATALIA V.;KOTOV, ALEXANDER U.;SHPEN, VLADIMIR M.;KAUROV, OLEG A.;KETLINSKY, SERGEY A. |
分类号 |
A61K31/305;A61K31/381;C07D209/20;C07D333/22;(IPC1-7):A61K38/06;A61K31/38;A61K31/40;C07D333/06 |
主分类号 |
A61K31/305 |
代理机构 |
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