发明名称 |
Method for determining precorneal retention time of ophthalmic formulations |
摘要 |
Apparatus and method for measuring ophthalmic formulation retention on the surface of an eye include dissolving a fluorescent macromolecule in an ophthalmic formulation to form a fluorescently labelled formulation; topically administering the fluorescently labelled formulation to an eye, said fluorescently labelled formulation forming a thin film on the eye surface. Apparatus is provided for illuminating the eye to cause fluorescence of the fluorescently labelled formulation as the fluorescently labelled formulation thin film is eliminated from the eye by normal blinking and lacrimation; and for measuring fluorescence from the thin film as a function of time.
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申请公布号 |
US5634458(A) |
申请公布日期 |
1997.06.03 |
申请号 |
US19930176768 |
申请日期 |
1993.12.30 |
申请人 |
ALLERGAN, INC. |
发明人 |
JOSHI, ABHAY;MEADOWS, DAVID;PAUGH, JERRY |
分类号 |
A61B3/12;A61B3/135;(IPC1-7):A61B5/00;A61B6/00 |
主分类号 |
A61B3/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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