| 发明名称 |
Method of reducing TNF alpha levels with amino substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxo-and 1,3-dioxoisoindolines |
| 摘要 |
1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines substituted with amino in the benzo ring reduce the levels of TNF alpha in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline.
|
| 申请公布号 |
US5635517(A) |
申请公布日期 |
1997.06.03 |
| 申请号 |
US19960690258 |
申请日期 |
1996.07.24 |
| 申请人 |
CELGENE CORPORATION |
发明人 |
MULLER, GEORGE W.;STIRLING, DAVID I.;CHEN, ROGER S. -C. |
| 分类号 |
A61K31/445;C07D401/04;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/445 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
