发明名称 |
Surface modified liposomes |
摘要 |
<p>A liposome reagent encapsulating a molecule to be targeted to a body site or used as an assay reporter has a ligand and a sulfonate-containing group on the liposome surface. Preferred ligands are antibodies or antibody fragments and preferred encapsulants are enzymes or dyes. In the most preferred reagents, the antibody and sulfonate-containing group are covalently bonded to the liposome surface through a connecting group which includes a succinimidyl group resulting from addition of the ligand or sulfonate-containing group to a maleimidyl group. The invention includes a kit of materials for performing an assay using the reagent of the invention as the tracer.</p> |
申请公布号 |
EP0524804(B1) |
申请公布日期 |
1997.05.14 |
申请号 |
EP19920306685 |
申请日期 |
1992.07.22 |
申请人 |
BECTON DICKINSON AND COMPANY |
发明人 |
RUTNER, HERMAN;READIO, JOSEPHINE D.;OPPENHEIMER, LESLIE |
分类号 |
G01N33/544;A61K9/127;G01N33/543;G01N33/58;(IPC1-7):G01N33/58 |
主分类号 |
G01N33/544 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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