发明名称 |
PROINSULIN PEPTIDE COMPOUNDS FOR DETECTING AND TREATING TYPE I DIABETES. |
摘要 |
<p>Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.</p> |
申请公布号 |
MX9700198(A) |
申请公布日期 |
1997.04.30 |
申请号 |
MX19970000198 |
申请日期 |
1995.07.07 |
申请人 |
TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
WILLIAM F. HICKEY;ANN C. GRIFFIN |
分类号 |
G01N33/53;A61K38/00;A61K38/28;A61P3/08;A61P3/10;C07K7/06;C07K7/08;C07K14/62;C07K14/74;C07K16/26;C12N15/00;C12P21/02;G01N33/50;(IPC1-7):C07K14/62;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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