| 摘要 |
This invention provides substituted heteroaromatic ring derivatives which are represented by a general formula ÄIÜ below: <CHEM> Äin the formula, R<1> and R<2> may be same or different and each signifies hydrogen, halogen or lower alkyl; R<3> signifies C3-C6 cycloalkyl or cycloalkenyl; R<4> signifies a heteroaromatic ring group which may be condensed with a benzene ring and which has 1 or 2 hetero atoms selected from a group consisting of nitrogen, oxygen and sulfur atoms (said heteroaromatic ring group being optionally substituted with lower alkyl, halogen, lower alkoxy, amino or hydroxymethyl); and X stands for O or NHÜ or their pharmaceutically acceptable salts. The substituted heteroaromatic ring derivatives of the present invention have selective M3 muscarinic receptor antagonist activity, and hence they are useful as therapeutic or prophylactic agents which are safe and efficacious with little side effects, of respiratory diseases such as asthma, chronic airway obstruction and pulmonary fibrosis, etc.; urinary diseases which induce such urination disorders as pollakiurea, urgency and urinary incontinence, etc.; and gastrointestinal diseases such as irritable bowel syndrome, spasm of gastrointestinal tract and gastrointestinal hyperkinesis. |
