| 摘要 |
<p>The invention concerns novel heterocyclically-substituted 1-indole carboxamides of general formula (I) in which: A means a mono or polycyclic 5 to 12-member heteroaryl group with 1 to 4 heteroatoms such as O, S or N which can optionally be substituted by lower alkyl, perfluoro lower alkyl, lower alkoxy, halogen or nitro; B means a mono or polycyclic 5 to 12-member aryl or heteroaryl group with 1 to 4 heteroatoms such as O, S or N which can optionally be substituted by lower alkyl, perfluoro lower alkyl, lower alkoxy, lower alkylthio, acetyl, lower alkoxy carbonyl, methylsulphonyl, halogen, cyano or nitro; X means hydrogen or a mono or polycyclic 5 to 12-member aryl or heteroaryl group with 1 to 4 heteroatoms such as O, S or N, which can optionally be substituted by lower alkyl, perfluoro lower alkyl, lower alkoxy, halogen or nitro; and R means hydrogen, (a), in which R1 means lower alkyl and R2 means lower alkyl, aryl or -OR3 with R3 meaning lower alkyl, cycloalkyl with 4 to 8 carbon atoms or aryl. The invention further concerns their pharmaceutically acceptable salts, a process for preparing these substances and their use.</p> |
