SYNTHESIS OF PEPTIDAMIDES BY THE SOLID PHASE METHOD USING ANCHOR GROUPS UNSTABLE AS TO ACIDS

摘要

Novel compounds of the formula …… in which R<1> denotes (C1-C8)-alkyl or optionally substituted (C6-C14)-aryl, R<2> denotes hydrogen or an amino acid radical which is protected by an amino protective group which can be removed by a weak acid or base, R<3> denotes hydrogen or (C1-C4)-alkyl and Y<1>-Y<9> denote identical or different radicals of hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy or -O-(CH2)n-COOH, (with n = 1 to 6), where one of these radicals is -O-(CH2)n-COOH. …A process for their preparation and the synthesis of peptide amides by the solid phase method using these novel compounds (spacers) are described.