Process for the preparation of biphenyl derivatives

摘要

Biphenyl derivatives and processes for the preparation of biphenyl derivatives are described. A compound of formula (I) is disclosed <IMAGE> (I) in which the substituent X is -CHO or -CH(OR1)OR2, where R1 and R2 independently of one another are (C1-C6)-alkyl or R1 and R2 together are an alkylene group (-CH2)n-, where n is 2, 3 4 or 5 and R is -F, -Cl, -NO2, -(CH2)m-COOR3, -(CH2)m-CONHR3, -(CH2)m-CN, -SO2NH-COOR3, -SO2NH-CO-NHR3, -SO2NH-SO2-R3, -NHSO2R3, <IMAGE> -PO3R3, -NH-SO2-CF3, -SO2NR4 where R3 is hydrogen, (C1-C6)-alkyl, (C3-C6)cycloalkyl, or (C1-C6)-alkyl-(C3-C6)cycloalkyl and R4 is a group =C-N(CH3)2, and m is 0, 1, 2, 3, or 4. The invention also relates to a process for the preparation of a compound of the formula (I) in which X is an optionally protected formyl group and R is a group which is itself inert to the reaction conditions of the synthesis, which comprises reacting a compound of the formula (II) <IMAGE> (II) with a substituted phenyl-halogen compound of the formula (III) <IMAGE> (III) wherein the substituent Hal is a halogen group.