| 摘要 |
PCT No. PCT/JP93/01412 Sec. 371 Date Apr. 3, 1995 Sec. 102(e) Date Apr. 3, 1995 PCT Filed Oct. 1, 1993 PCT Pub. No. WO94/07890 PCT Pub. Date Apr. 14, 1994A pyrimidine derivative represented by the formula (II) or (III): <IMAGE> (II) <IMAGE> (III) (wherein R1 and R2 each represent H, a halogen, amino, nitro, an unsubstituted or substituted alkyl, an alkoxy or an alkoxycarbonyl, or R1 and R2 are bonded together to form an unsubstituted or substituted alkylene; R3 represents an aralkyl or a hetero aromatic ring type-alkyl, R4 represents H or acyl, R5 represents H, OH or an alkoxy, R6 represents H, a halogen, an alkyl or an alkoxy, X represents -CH=, -CH=CH-(CH2)p-, -CH2- or -CH2CH2-(CH2)p-, Y represents =CH- (CH2)p-, -CH2-(CH2)p-, a single bond or a double bond, p represents 0 or 1, and +E,ovs . . .+EE represents a single bond or a double bond), and a salt thereof have selective acetylcholinesterase-inhibiting activities and selective A type monoamine oxidase-inhibiting activities, and are useful as an antidepressant and an agent for curing senile dementia.
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