| 摘要 |
<p>The subject-matter of the invention is a process for the preparation of tablets or film-coated tablets with increased active ingredient release, said tablets comprising as active ingredients a mixture of L-3,4-di-(hydroxy)-phenylalanine and L-alpha-(hydrazino)-alpha-(methyl)-3,4-di-(hydroxy)-phenyl propionic acid, by admixing any of L-3,4-di-(hydroxy)-phenylalanine and L-alpha-(hydrazino)-alpha-(methyl)-3,4-di(hydroxy)-phenyl propionic acid, or both of them, with hydrophilic diluents, and optionally with colouring agents, blending the mixture thus obtained with auxiliary agents conventionally used for the preparation of tablets and optionally with the other active ingredient, moreover with a solution of stearin in an organic solvent, optionally containing auxiliary agents conventionally used for the preparation of tablets, drying and granulating the mixture thus obtained, optionally admixing further auxiliary agents to the dry granulate, compressing it into tablets and, if desired, applying a film-coating onto the surface of the tablets thus obtained. The process according to the invention provides tablets of appropriate quality with rapid active ingredient release.</p> |
