| 发明名称 |
Novel human tissue-type plasminogen activator variant |
| 摘要 |
<p>Novel human tissue-type plasminogen activator variant that a) retains substantially full biological activity, b) has a modified carbohydrate structure and c) has an altered in vivo half-life. Mains for preparation of the variants and results of assays measuring function of the activators are also disclosed. <IMAGE></p> |
| 申请公布号 |
EP0754753(A1) |
申请公布日期 |
1997.01.22 |
| 申请号 |
EP19960113810 |
申请日期 |
1988.11.02 |
| 申请人 |
GENENTECH, INC. |
发明人 |
HOTCHKISS, ADAIR J.;SPELLMAN, MICHAEL W.;O'CONNOR, JOHN V. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/46;A61P7/02;C12N9/64;C12N9/72;C12N15/58;(IPC1-7):C12N9/64;A61K38/49 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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