4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY

摘要

Compounds of formula (I), wherein Y is -CH- or -N-; R1 is hydrogen, halogen, a CF3 group, (C3-4) alkyl or (C1-4) alkoxyl; R2 is hydrogen, halogen, hydroxyl, a CF3 group, (C3-4) alkyl or (C1-4) alkoxyl; each of R3 and R4 is hydrogen or (C1-3) alkyl; X is (a) (C3-6) alkyl, (C3-6) alkoxyl, (C3-7) carboxyalkyl, (C1-4)alkoxycarbonyl(C3-6)alkyl, (C3-7) carboxyalkoxyl or (C1-4)alkoxycarbonyl(C3-6)alkoxyl; (b) a radical selected from (C3-7) cycloalkyl, (C3-7) cycloalkyloxy, (C3-7) cycloalkylmethyl, (C3-7) cycloalkylamino and cyclohexenyl, said radical being optionally substituted by halogen, hydroxy, (C1-4) alkoxy, carboxy, (C1-4) alkoxycarbonyl, amino, mono- or di-(C1-4)alkylamino; or (c) a group selected from phenyl, phenoxy, phenylamino, N-(C1-3) alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulphonyl, phenylsulphinyl or styryl, said group being optionally mono- or polysubstituted on the phenyl group by halogen, CF3, (C1-4)alkyl, (C1-4)alkoxy, cyano, amino, mono- or di-(C1-4)alkylamino, (C1-4)acylamino, carboxy, (C1-4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-4)alkylaminocarbonyl, amino(C1-4)alkyl, hydroxy(C1-4)alkyl or halo(C1-4)alkyl; and salts, solvates and quaternary ammonium salts thereof; a method for preparing said compounds; and pharmaceutical compositions containing same, are disclosed. Said compounds have neurotrophic and neuroprotective activity.