UN PROCEDIMIENTO PARA LA PREPARACION DE 13 BETA-ETIL-17 AL-FA - ETINIL-17-HIDROXIGON-4-EN-3-ONA.

摘要

1,207,048. 2-Alkyl-4-oxa-steroids. F. HOFFMAN-LA ROCHE & CO. A.G. 1 Nov., 1968 [2 Nov., 1967], No. 51935/68. Heading C2C. The invention comprises compounds of formula wherein m is 1 or 2, R1 is C 1-5 primary alkyl, R3, R4, R7 and R8 are each H or C 1-8 alkyl, R5 is C 1-8 alkyl, R2 is H, R6 is OH, or R2 and R6 together represent an extra bond, Z is carbonyl or C(#-OR9)(α-R10) wherein R9 is H or C 1-7 acyl and R10 is H or C 1-5 hydrocarbyl, and the wavy lines indicateαor #-configurations. The compounds wherein R2 + R6 represent an extra bond are prepared by acid cyclization of compounds of formula wherein R11 is C 1-8 alkoxy, and are converted to the compounds wherein R2 is H and R6 is OH by treatment with aqueous acid. The conversion of compounds of Formula I into steroids and the preparation of compounds of Formula II are described as in Specification 1,207,047.