发明名称 |
Viral integrase inhibiting peptides |
摘要 |
The present invention provides viral integrase inhibiting peptides having the general structure, <IMAGE> (SEQ ID NO: 1) where Xaa is an amino acid or an amino acid analog, the stereochemistry of the amino acids or amino acid analogs can be D-amino acids or L-amino acids and the amino and carboxy termini of the peptide can be modified. The invention also provides viral inhibiting peptides having essentially the amino acid sequence, <IMAGE> (SEQ ID NO: 28) The invention also provides a pharmaceutical composition comprising a viral integrase inhibiting peptide and methods of using a viral integrase inhibiting peptide in vitro or in vivo to reduce or inhibit viral integrase activity in a cell and the infectivity of a virus.
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申请公布号 |
US5578573(A) |
申请公布日期 |
1996.11.26 |
申请号 |
US19950375911 |
申请日期 |
1995.01.20 |
申请人 |
HOUGHTEN PHARMACEUTICALS, INC. |
发明人 |
HOUGHTEN, RICHARD A.;WEBER, PATRICIA A.;PLASTERK, RONALD H. A.;PURAS LUTZKE, RAMON A. |
分类号 |
C07K7/06;(IPC1-7):A61K38/08;C12N9/12 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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