| 摘要 |
<p>An animal model having the circulatory physiology of the fatal human infant condition of transposition of the great arteries (TGA) is created by surgically altering the normal animal heart, and the surgical correction of this fatal physiology by simultaneously altering the normal animal vasculature. The result of performing these two procedures simultaneously in a normal animal is that the heart chamber (4) that normally pumps deoxygenated blood (22) to the lungs (7) is switched to pump oxygenated blood (23) to the body (16), and the chamber (11) that normally pumps oxygenated blood (23) to the body (16) is switched to pump deoxygenated blood (22) to the lungs (7). Such unusual circulatory connections are present in humans who have the condition known as congenitally corrected transposition of the great arteries (corrected TGA). The model is useful for surgical training, the design of safer TGA corrections, and clinical studies involving the consequences of switching the pumping roles of right and left ventricles.</p> |
