| 摘要 |
FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention relates to a novel cryptoficine compound of the formula (I) where Ar means methyl or phenyl or any simple unsubstituted or substituted aromatic or heterocyclic group; R1 means halogen atom; R2 means OH; or R1 and R2 can be joined to form epoxy-ring, aziridine ring; R1 and R2 can be joined in common to form a double bond between C18 and C19; R3 means lower alkyl group; R4 and R5 mean H; or R4 and R5 can be joined to form a double bond between C13 and C14; R6 means benzyl, hydroxybenzyl (oxybenzyl), alkoxybenzyl, halogenoxybenzyl, dihalogenoxybenzyl, halogenalkoxy-benzyl or dihalogenalkoxybenzyl group; R7, R8, R9, R10 each means independently H or lower alkyl group; X and Y each means independently O, NH. Compounds can be used for inhibition of proliferation of cells in mammal and for treatment of tumors. Invention describes also pharmaceutical composition based on compounds and methods of using. EFFECT: improved method of treatment, valuable medicinal properties of compounds. 56 cl, 10 tbl, 14 dwg, 22 ex |
