PROTEINES MUTEES, CODEES PAR UN GENE ENV MUTE DE LENTIVIRUS, FRAGMENTS PEPTIDIQUES INCLUS DANS LESDITES PROTEINES, VECTEURS D'EXPRESSION EXPRIMANT LESDITES PROTEINES MUTEES ET LEURS APPLICATIONS

摘要

Mutated proteins coded by a mutated env gene of a lentivirus, particularly FIV, HIV or CAEV, peptide fragments contained in said mutated proteins and expression vectors expressing said mutated proteins as well as the applications thereof are described. The peptide fragments are contained in the principal immunodominant domain (PID) of the transmembrane protein (TM) of lentiviruses and particularly of feline immunodeficiency virus (FIV), human immunodeficiency virus (HIV-1 and HIV-2), arthritis virus and caprine encephalitis virus (CAEV), and are capable of modifying the immunogenic properties of the PID domain and of the Env protein of the lentiviruses containing them. Such fragments have one of the following sequences: SEQ ID N DEG 1: CNQNQWLCK, SEQ ID N DEG 2: CNQNQFLCK, SEQ ID N DEG 3: CNQNQLWCK, SEQ ID N DEG 4: CNQNQPFCK, SEQ ID N DEG 5: CEHQHFFCK, SEQ ID N DEG 6: CSMGTFFCK, SEQ ID N DEG 7: CLTDSFFCK, SEQ ID N DEG 8: CELKNFFCK, SEQ ID N DEG 9: CRPAAFFCK, SEQ ID N DEG 10: ELGCGSKLICKIP, SEQ ID N DEG 11: IWGCNQNQFFCTTAVPWN, SEQ ID N DEG 12: IWGVAFRQVCTTAVPW.