BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS

摘要

Compounds of formula (I), wherein X represents a single bond, O, S or CR9R10 where R?9 and R10¿ each independently represent a hydrogen atom or a C¿1-4?alkyl group; R?1a, R1b and R1c¿ each independently represent a substituent selected from: a hydrogen or halogen atom, a hydroxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, C¿1-4?alkyl, C1-4alkoxy, C1-4alkylthio, C1-4alkoxyC1-4alkyl, C3-6cycloalkylC1-4alkoxy, C1-4alkanoyl, C1-4alkoxycarbonyl, C1-4alkylsulphonyl, C1-4alkylsulphonyloxy, or C1-4alkylsulphonylC1-4alkyl, arylsulphonylarylsulphonyloxy or arylsulphonylC1-4alkyl group, or a group R?11¿OCO(CH¿2?)p, R?11R12¿NCO(CH¿2?)p or R?11R12NSO¿2(CH2)p where each of R?11 and R12¿ independently represents a hydrogen atom or a C¿1-4?alkyl group and p represents zero or an integer from 1 to 4; R?2, R3, R4 and R5¿ each independently represent a hydrogen atom or a C¿1-4?alkyl group; R?6¿ represents a hydrogen atom or a C¿1-6?alkyl, C3-6alkenyl or arylC1-4alkyl group; R?7¿ represents a hydrogen atom or a C¿1-4?alkyl group; and R?8¿ represents a group of structure (a), (b) or (c) and salts thereof are useful in therapy, as modulators of D¿3? receptors, in particular as antipsychotic agents.