发明名称 |
Method of preparing polypeptide binding compositions derived from immunoglobulin variable regions |
摘要 |
Proteinaceous binding compositions are prepared employing hybrid DNA technology, where the variable region polypeptides of immunoglobulins are substantially reproduced to provide relatively small protein molecules having binding specificity and lacking the undesirable aspects of the heavy regions of immunoglobulins. The compositions find a wide range of use, particularly for physiological purposes for diagnosis and therapy. The binding compositions may be modified by labeling with radioisotopes, fluorescers, and toxins for specific applications in diagnosis or therapy.
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申请公布号 |
US5851801(A) |
申请公布日期 |
1998.12.22 |
申请号 |
US19950460892 |
申请日期 |
1995.06.05 |
申请人 |
SCHERING CORPORATION |
发明人 |
MOORE, KEVIN W.;ZAFFARONI, ALEJANDRO |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P37/00;C07H21/04;C07K1/22;C07K14/00;C07K16/00;C07K19/00;C12N1/00;C12N15/00;C12N15/10;C12P21/00;C12P21/08;C12R1/125;C12R1/19;C12R1/865;G01N33/531;G01N33/577;(IPC1-7):C12P21/00;C12N15/13 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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