发明名称 |
PREPARATION OF TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES |
摘要 |
The invention relates to a process for converting Taxol A, B and C to Taxol primary amine which can then be easily and efficiently converted to Taxol A or docetaxel, thereby significantly increasing the yield of these products from biomass. The method includes the removal of the amide from the side-chain with Schwartz's reagent to form an imine, followed by the hydrolysis of the imine to the primary amine. The primary amine can then be converted to Taxol A or docetaxel. New Taxol imine compounds and primary amine salts have been formed by this process.
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申请公布号 |
CA2211799(A1) |
申请公布日期 |
1996.08.08 |
申请号 |
CA19962211799 |
申请日期 |
1996.01.30 |
申请人 |
HAUSER, INC.;HAUSER INC |
发明人 |
MURRAY, CHRISTOPHER K.;CHENG, XIAOQIN;PETERSON, S. KENT;ZHENG, QUN Y. |
分类号 |
C07D305/14;(IPC1-7):C07D305/14;C07F7/10;C07H15/26 |
主分类号 |
C07D305/14 |
代理机构 |
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主权项 |
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地址 |
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