GLUBODIES - MULTIPLICITIES OF PROTEINS CAPABLE OF BINDING A VARIETY OF SMALL MOLECULES

摘要

Certain naturally occurring proteins contain regions, designated protogludomains, which can be modified randomly or systematically to generate families of protein ligates, termed glubodies, which have ranges and variations in binding specificities comparable to those of the antibody repertoire. Methods for constructing such families of glubodies and for their use are described.