发明名称 |
SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS |
摘要 |
Compounds of formula (I) are described, wherein: R1 is CN, CH2CN, CH=CHCN, CHO, or CH=CHCO2H; R2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio in which each of the aryl and heteroaryl moieties is optionally substituted; R3 is halogen; R4 is optionally substituted aryl or optionally substituted heteroaryl; R5 is carboxy or an acid isostere; X is oxygen or sulphur; and n is zero or 1; and their N-oxides and prodrugs, and pharmaceutically acceptable salts thereof. The compounds have endothelin antagonist activity and are useful as pharmaceuticals.
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申请公布号 |
CA2211646(A1) |
申请公布日期 |
1996.08.01 |
申请号 |
CA19962211646 |
申请日期 |
1996.01.22 |
申请人 |
RHONE POULENC RORER LIMITED |
发明人 |
MCLAY, IAIN MCFARLANE;SMITH, CHRISTOPHER;HALLEY, FRANK;BRIDGE, ANDREW WILLIAM;MORLEY, ANDREW DAVID;MAJID, TAHIR NADEEM;VAN SICKLE, ANDREW PAUL;WALSH, ROGER JOHN AITCHISON;ASTLES, PETER CHARLES;MCCARTHY, CLIVE;PORTER, BARRY;HARRIS, NEIL VICTOR |
分类号 |
A61K31/275;A61K31/34;A61K31/357;A61K31/36;A61K31/38;A61K31/381;A61K31/41;A61K31/42;A61K31/425;A61K31/426;A61K31/44;A61K31/50;A61P9/10;A61P25/00;A61P43/00;C07C255/54;C07D213/30;C07D213/61;C07D237/08;C07D263/56;C07D275/02;C07D277/24;C07D307/12;C07D317/54;C07D333/16;C07D405/12;C07D411/12;(IPC1-7):C07D213/57;C07D271/06;C07D261/08;C07D231/12;C07D401/12;C07D409/12;C07D333/24;C07D239/26;C07D277/30;A61K31/335;A61K31/435;A61K31/495;C07D307/54;C07D317/60 |
主分类号 |
A61K31/275 |
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