发明名称 Phosphonosuccinic acid derivatives, processes for their preparation and medicaments containing these compounds
摘要 PCT No. PCT/EP92/02890 Sec. 371 Date Jun. 3, 1994 Sec. 102(e) Date Jun. 3, 1994 PCT Filed Dec. 14, 1992 PCT Pub. No. WO93/12122 PCT Pub. Date Jun. 24, 1993 <IMAGE> (I) Compounds of the formula (I) in which: R is a possibly substituted amino group of the general form -NR1R2, in which R1 and R2 are independently hydrogen, lower alkyl, lower alkenyl or lower alkinyl, or R is a saturated, unsaturated or aromatic heterocyclic ring which may be mono or bi-substituted by lower alkyl or halogen; alk is a valency bond, a methylene, a saturated or unsaturated, straight or branched-chain alkylene chain with 2-6 carbon atoms; and R3, R4, R5 are independently hydrogen, lower alkyl or benzyl; and their pharmacologically acceptable salts and enantiomers where, if R3=R4=R5=CH3 and alk is a valency bond, R may not be the dimethyl amino group. Process for their production and medicaments containing these compounds, for the treatment of calcium metabolic complaints.
申请公布号 US5538957(A) 申请公布日期 1996.07.23
申请号 US19940244245 申请日期 1994.06.03
申请人 BOEHRINGER MANNHEIM GMBH 发明人 TSAKLAKIDIS, CHRISTOS;BOSIES, ELMAR;ESSWEIN, ANGELIKA;BAUSS, FRIEDER
分类号 A61K31/66;A61K31/662;A61K31/675;A61P3/00;A61P3/14;C07F9/38;C07F9/40;C07F9/553;C07F9/572;C07F9/58;C07F9/6506;C07F9/6509;(IPC1-7):A61K31/66;C07C229/24 主分类号 A61K31/66
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