| 发明名称 |
METHODS FOR INHIBITING GRAFT VERSUS HOST DISEASE IN BONE MARROW TRANSPLANTATION |
| 摘要 |
Methods for inhibiting antigen-specific T cell responses in vitro by use of an agent which inhibits a costimulatory signal in T cells, such as a CTLA4Ig fusion protein or an anti-B7-1 antibody or an anti-B7-2 are disclosed. The methods of the invention are particularly useful for inhibiting graft versus host disease which results from allogeneic bone marrow transplantation.
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| 申请公布号 |
WO9614865(A1) |
申请公布日期 |
1996.05.23 |
| 申请号 |
WO1995US14774 |
申请日期 |
1995.11.09 |
| 申请人 |
REPLIGEN CORPORATION;DANA-FARBER CANCER INSTITUTE |
发明人 |
GRIBBEN, JOHN, G.;NADLER, LEE, M.;GRAY, GARY, S. |
| 分类号 |
A61K38/00;A61K38/17;C07K16/28;(IPC1-7):A61K39/00 |
主分类号 |
A61K38/00 |
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