| 摘要 |
A pharmaceutical compound of the formula <IMG> (I) in which R1 and R7 are each halo, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl, R2 and R3 are each hydrogen or C1-6 alkyl, R4 and R5 are each hydrogen, halo, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl, R6 is hydrogen, C1-6 alkyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heteroaryl, optionally substituted phenyl-C1-6 alkyl or -CO2R8 where R8 is an ester group, m and p are each 0, 1, 2, 3 or 4, n is 1, 2, 3 or 4, Z is <IMG> , ?O? , ?S? or <IMG> where R9 and R10 are each hydrogen, C1-6 alkyl or optionally substituted phenyl-C1-6 alkyl, X is oxygen or sulphur, and Y is <IMG> or <IMG> where R11 and R12 are each hydrogen, C1-6 alkyl, trifluoromethyl, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl; and salts and solvates thereof.
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