发明名称 |
NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS |
摘要 |
Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate of general formula (I), wherein R<1> is -CCH, -CH=CH2 or -CH2-CH3, R<2> is a saturated, unsaturated, branched or unbranched C1-C30 alkyl group which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon,or heterocyclic group. M is a hydrogen or a metal atom. Formula (I) is not 2-n-propyl-4-pentynoic acid (4-yn-VPA) or 2-n-propyl-4-pentenoic acid (4-en-VPA) and when R<1> is -CH2-CH3, R<2> is C5 to C30. This invention also provides a method of making the compounds of the invention. The compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.
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申请公布号 |
WO9606821(A1) |
申请公布日期 |
1996.03.07 |
申请号 |
WO1995US10775 |
申请日期 |
1995.08.25 |
申请人 |
AMERICAN BIOGENETIC SCIENCES, INC.;UNIVERSITY COLLEGE DUBLIN;REGAN, CIARAN, M. |
发明人 |
REGAN, CIARAN, M.;NAU, HEINZ |
分类号 |
A61K31/19;A61P25/00;A61P25/28;A61P43/00;C07C51/38;C07C53/128;C07C57/02;C07C57/03;C07C57/18;(IPC1-7):C07C57/03 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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