| 摘要 |
<p>The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers.</p> |
| 申请人 |
MYRIAD GENETICS, INC.;UNIVERSITY OF UTAH RESEARCH FOUNDATION;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SKOLNICK, MARK H.;GOLDGAR, DAVID E.;MIKI, YOSHIO;SWENSEN, JEFF;KAMB, ALEXANDER;HARSHMAN, KEITH D.;SHATTUCK-EIDENS, DONNA M.;TAVTIGIAN, SEAN V.;WISEMAN, ROGER W.;FUTREAL, P.ANDREW |
