| 摘要 |
PCT No. PCT/JP93/01339 Sec. 371 Date May 17, 1994 Sec. 102(e) Date May 17, 1994 PCT Filed Sep. 17, 1993 PCT Pub. No. WO94/06785 PCT Pub. Date Mar. 3, 1994.The present invention discloses sulfonamide derivative represented by the following general formula: <IMAGE> [wherein, R1 is (i) -COOR2 (where, R2 is (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) an alkyl having 1 to 14 carbon atoms) or, (ii) -C(=O)-R3 (wherein, R3 represents an alkyl having 1 to 4 carbon atoms); A is (i) -(CH2)n- (wherein, n represents an integer of 0 to 3), (ii) -CH=CH-, or the group: (iii) -O-C(R4) (R5)- (wherein, R4 and R5 represent (1) hydrogen or (2) an alkyl having 1 to 4 carbon atoms, and R4 and R5 may be identical or different); and, w is NH or -O-], as well as a thromboxane A2 receptor antagonistic drug having said derivative for its active ingredient. Since the compound of the present invention has excellent thromboxane A2 receptor antagonistic action, it can be used as a thromboxane A2 receptor antagonist of high activity and long duration.
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