Pulsatile delivery systems of biologically active agents using electro voltage pulsing for controlling membrane permeability

摘要

The invention relates to a method for pulsed transport of a substance through tissue, the method comprising the steps of: (a) applying at least one electrical pulse to the tissue causes electroporation of the tissue region, the electrical pulse being applied for an electroporation pulse duration, the electroporation pulse duration being shorter than the driving force duration; (b) applying a driving force to the region of tissue whereby the driving force causes the substance to be transported through the tissue for a driving force duration; and (c) repeating step (a) during the driving force duration.