POLYMER MICROPARTICLES FOR DRUG DELIVERY

摘要

The invention provides a microparticle comprising a mixture of a biodegradable polymer and a water soluble polymer, and an active agent. Preferred biodegradable polymers are lactide homopolymers or copolymers of lactide and glycolide. Preferred water soluble polymers are PEG (poly(ethylene glycol)) or PEG copolymers. The particles exhibit a linear release profile of active agent. The invention also provides an emulsion/solvent extraction method to make the microparticles. The continuous phase of the secondary emulsion contains an organic solvent which is miscible with the organic solvent in the primary emulsion.