发明名称 |
Process for preparing ondansetron |
摘要 |
The invention relates to carbazolone derivatives of the formula <IMAGE> (I) wherein A stands for a group of formula -CH2-R(V), wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group; B represents a group of formula <IMAGE> (VI) wherein R1 means hydrogen or a methyl or ethyl group; or A and B together form a group of formula <IMAGE> (VII) wherein R2 means a methyl or ethyl group; or A and B together form a group of formula <IMAGE> (VIII) The above compounds are useful intermediates in the synthesis of ondansetron of formula <IMAGE> (II) chemically 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-c arbazol-4-one. The invention further relates to a novel process for the preparation of compounds of the formula (I) , wherein A and B are the same as in formula (I) but B may be also hydrogen. Thus, this novel process is suitable for the preparation of ondansetron itself.
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申请公布号 |
US5478949(A) |
申请公布日期 |
1995.12.26 |
申请号 |
US19940344871 |
申请日期 |
1994.11.25 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT. |
发明人 |
BOD, PETER;HARSANYI, KALMAN;TRISCHLER, FERENC;FEKECS, EVA;CSEHI, ATTILA;HEGEDUES, BELA;MERSICH NEE DONAT, EVA;SZABO NEE KOMLOSI, GYOERGYI;HORVATH NEE SZIKI, ERIKA |
分类号 |
A61K31/40;A61K31/403;A61K31/415;A61P1/08;C07D209/88;C07D209/96;C07D403/04;C07D403/06;C07D491/10;C07D491/107;(IPC1-7):C07D403/06 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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