PROCESS FOR PRODUCING OPTICALLY ACTIVE PROPARGYL ALCOHOL COMPOUND

摘要

A process for stereoselectively obtaining an optically active O-acylpropargyl alcohol compound represented by general formula (2) (wherein R<1> and R<2> represent each hydrogen or C1-C3 alkyl; R<3> represents phenyl which may be substituted by C1-C5 alkyl, halogeno or trifluoromethyl at an arbitrary position of the ring, C1-C8 alkyl or C5-C8 cycloalkyl; R<4> represents C1-C10 alkyl or phenyl which may be substituted by phenyl or halogeno at an arbitrary position of the ring; and the asterisk represents optical activity) by the reaction of an (RS)-propargyl alcohol compound represented by general formula (1) (wherein R<1>, R<2> and R<3> are each as defined above) with an acylating agent R<4>COOR (wherein R<4> is as defined above; and R represents arbitrary alkyl or alkenyl) in the presence of an enzyme; and a process for obtaining an optically active propargyl alcohol compound either by hydrolyzing the above O-acyl compound or from the solution of the above acylation reaction.