METHOD FOR PREPARING HOMOCHIRAL MALEIMIDE INTERMEDIATES, VIA SILYLATION TECHNIQUES, USED IN THE ENANTIOSELECTIVE PREPARATION OF ANTI-THROMBOTIC AND ANTI-VASOSPASTIC COMPOUNDS

摘要

A method is provided for preparing homochiral maleimide intermediates of the structure <IMG> wherein R7, R8 and R9 are as defined herein by reacting a homochiral amine of the structure <IMG> with maleic anhydride and a silylating agent. The maleimide intermediate is used in the enantioselective preparation of thromboxane A2 receptor antagonists.