| 发明名称 |
Inhibitors of farnesyl-protein transferase |
| 摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer. |
| 申请公布号 |
AU1988495(A) |
申请公布日期 |
1995.10.03 |
| 申请号 |
AU19950019884 |
申请日期 |
1995.03.10 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
S. JANE DESOLMS;SAMUEL L. GRAHAM |
| 分类号 |
A61K31/40;A61K31/443;A61K31/445;A61K31/47;A61K31/472;A61K38/55;A61P35/00;A61P43/00;C07D207/16;C07D211/60;C07D217/26;C07D403/12;C07D405/12;C07K5/078;C07K5/087;C07K5/097 |
主分类号 |
A61K31/40 |
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