| 摘要 |
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula <IMG> their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein: A1 and A2 are each independently H, alkyl, substituted alkyl, phenyl or substituted phenyl Y and Z are each independently -CH2- or -C(O)-; R1 and R2 are each independently H or alkyl; R1 and A1 taken together may be -(CH2)m-R3 is H, alkyl or phenyl; J, K and L are each independently, N, NR4, O, S or CR5 with the provisos that only one of the groups J, K and L can be O or S, one or two of the groups J, K and L may be N or NR4, and at least one of the groups J or L must be N, NR4, O or S to form a fused five-membered heteroring; the bond between J and K or K and L may also form one side of a phenyl ring fused to the fused five-membered heteroring; x is O or NR6; R4 is H, alkyl or phenylalkyl; R5 is H or alkyl; R6 is H, alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl or C(O)R7; R7 is H, alkyl, phenyl or substituted phenyl; m is 3 or 4; p is 0, 1 or 2; and q is 0 or 1, with the proviso that when p is 0, q is also 0.
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