发明名称 |
INTRAMUSCULAR INJECTION FORMS OF GYRASE INHIBITORS |
摘要 |
Ciprofloxacin and related gyrase inhibitors are tolerated well if administered intramuscularly in the form of an aqueous suspension of the betaine form having an approximate neutral pH value or in the form of an oily suspension of the betaine or salts thereof. Oily suspensions which contain the active material in water-soluble form, eventually in form of the hydrochlorides, lactates, mesilates, methanesulfonates and other salts, are capable of releasing the active compound very rapidly, particularly when the wettability of the oily carrier medium is increased by addition of interfacially surface active materials.
|
申请公布号 |
CA1336822(C) |
申请公布日期 |
1995.08.29 |
申请号 |
CA19890596557 |
申请日期 |
1989.04.13 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
POELLINGER, NORBERT;SERNO, PETER;HOFMANN, WOLFRAM;BEERMANN, DIETER |
分类号 |
C07D215/56;A61K9/00;A61K9/08;A61K31/44;A61K31/445;A61K31/47;A61K31/495;A61K31/535;A61K31/54;A61P31/04;C07D401/04;C07D405/00;C07D471/08;C07D487/08;(IPC1-7):A61K31/395 |
主分类号 |
C07D215/56 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|