CLATHRATE COMPOUND WATER SOLUTION OF BENZOTHIOPHENE COMPOUND AND WATER-SOLUBLE CYCLODEXTRIN, MEDICINAL PREPARATION THEREOF, AND ITS APPLICATION OF USE

摘要

PURPOSE: To provide an aqueous inclusion complex that contains a certain known benzo[b]thiophene compound and water-soluble cyclodextrin and is useful for treatment of mammalian osteoporosis, hypercholesterolemia and the like. CONSTITUTION: The objective aqueous inclusion complex solution includes (A) a compound of the formula R<1> and R<2> are each H, methyl, -CO-alkyl of 1-6C or a group of the formula: -CO-Ar [Ar is a (substituted) phenyl], R<2> is pyrrolidino, hexamethylenimino or piperidino} their salt, for example, the hydrochloride of the compound of the formula where R<1> and R<3> are each H and R<2> is piperidino, and (B) a water-soluble cyclodextrin, for example, hydroxypropyl-β-cyclodextrin.