发明名称 |
HEXAHYDRONAPHTHALENE ESTERS AND RING CLOSED LACTONES; PREPARATION AND MEDICAMENTS |
摘要 |
<p>Compounds of formula (I): <CHEM> [wherein R<1> represents a group of formula (II) or (III): <CHEM> R<2> is alkyl, alkenyl or alkynyl; R<3> and R<4> are each hydrogen, alkyl, alkenyl or alkynyl; R<5> is hydrogen or a carboxy-protecting group; R<a> is hydrogen or a group of formula and -OR<6>; R<6>, R<6a> and R<6b> are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulphonyl, halogenated alkanesulphonyl or arylsulphonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.</p> |
申请公布号 |
NZ250609(A) |
申请公布日期 |
1995.07.26 |
申请号 |
NZ19930250609 |
申请日期 |
1993.12.23 |
申请人 |
SANKYO CO LTD |
发明人 |
KOGEN, HIROSHI;ISHIHARA, SADAO;KOGA, TEIICHIRO;KITAZAWA, EIICHI;SERIZAWA, NOBUFUSA;HAMANO, KIYOSHI |
分类号 |
A61K31/22;A61K31/35;A61K31/365;A61K31/366;A61P3/06;C07C69/03;C07C69/24;C07C69/33;C07C69/67;C07C69/675;C07C69/732;C07C69/734;C07D309/30;C12N9/02;C12P7/62;C12P17/06;C12R1/01;C12R1/465;C12R1/785 |
主分类号 |
A61K31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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