| 摘要 |
A method of inactivating viral molecules present within a blood sample and compounds for use in same. The method involves adding to a virus-containing blood sample an effective quantity of a compound which both has an affinity for viral nucleic acid and which is activatable to an excited state in which the compound covalently binds viral nucleic acid. After permitting the compound to complex with viral nucleic acid, the compound is raised to its excited state by chemical activation. In a first preferred embodiment, psoralen, hypericin or a derivative of psoralen or hypericin is used as the activatable, viral-inactivating compound, and chemical activation of the compound is effected by the decomposition of a dioxetane proximate to the nucleic acid/compound complex. In a second preferred embodiment, the activatable, viral-inactivating compound is incorporated into a dioxetane molecule, and chemical activation of the compound is effected by decomposition of the dioxetane into a pair of carbonyl compounds.
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