Substituted cyclic amine compounds as 5HT2 antagonists.

摘要

A substituted cyclic amine compound represented by the following general formula (1) wherein each of R<1> to R<5> represents a hydrogen atom, a hydroxyl group, an alkyl group or the like, D represents a methine moiety, a nitrogen atom or the like, P represents -CR<6>(R<7>)- or -NR<8>-, Q represents a methine moiety or a nitrogen atom, each of T and B is a single bond or represents a methylene moiety, a carbonyl group or the like, n is an integer of 1 to 6 and each of R<6>, R<7> and R<8> represents a hydrogen atom, an alkyl group or the like; and synthetic intermediates thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripherol circulatory disease and the like.