发明名称 Antagonists to chaperonin 10
摘要 Antibodies raised against recombinant or synthetic cpn10 are disclosed. The cpn10 has the sequence GSMAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQ ATVEAVGSGSKGKGGEIQPVSVKEGDKVLLPEYGGTKVVLDDKDYFLFRDGDIL GKYVD (SEQ ID NO: 21 ). Antibodies are raised against either the entire sequence of cpn 10, or a shorter peptide sequence derived from cpn 10, such as Ac-AGQAFRKFLPL (SEQ ID NO: 2 ), ACQAFRKFLPL (SEQ ID NO 1 ), or EKSQGKVLQAT (SEQ ID NO: 3 ), in which the peptides may have a single amino acid deletion, addition or substitution. The antibodies can be used to terminate pregnancy, suppress tumor cell growth or enhance the immune system.
申请公布号 AU1103695(A) 申请公布日期 1995.06.19
申请号 AU19950011036 申请日期 1994.11.30
申请人 THE UNIVERSITY OF QUEENSLAND 发明人 HALLE MORTON;ALICE CHRISTINA CAVANAGH
分类号 G01N33/53;A61K38/00;A61K39/395;A61K45/00;A61P5/00;A61P15/06;A61P15/08;A61P17/00;A61P17/02;A61P25/20;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/04;A61P37/06;A61P37/08;C07K7/06;C07K14/00;C07K14/47;C07K16/18;C12N15/09;C12P21/02;C12P21/08;C12R1/19 主分类号 G01N33/53
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