QUINOLINE TYPE MEVALONOLACTONES.

摘要

A compound of the formula: wherein R<1>, R<2>, R<3>, R<4> and R<6> are independently hydrogen, C1-6 alkyl, C1-6cycloalkyl, C1-3 alkoxy, n-botoxy, i-botoxy, sec-butoxy, R<7>R<8>N- (wherein R<7> and R<8> are independently hydrogen or C1-3 alkyl), trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoro, chloro, bromo, phenyl, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-t-butylsilyloxy, hydroxymethyl or -O(CH2) l OR<1><9> (wherein R<1><9> is hydrogen or C1-3 alkyl, and l is 1,2 or 3); or when located at the ortho position to each other, R<1> and R<2>, or R<3> and R<4> together form -CH=CH-CH=CH-; or when located at the ortho position to each other, R<1> and R<2> together form -OC(R<1><5>)(R<1><6>)O- (wherein R<1><5> and R<1><6> are independently hydrogen or C1-3 alkyl); Y is -CH2-, -CH2CH2-, -CH=CH-, -CH2-CH=CH- or -CH=CH-CH2-; and Z is -Q-CH2WCH2 CO2R<1><2>, (wherein Q is -C(O)-, -C(OR<1><3>)2- or -CH(OH)-; W is -C(O)-, -C(OR<1><3>)2- or -C(R<1><1>)(OH)-; R<1><1> is hydrogen atom or C1-3 alkyl; R<1><2> is hydrogen or R<1><4> (wherein R<1><4> is physiologically hydrolyzable alkyl or M (wherein M is NH4, sodium, potassium, 1/2 calcium or a hydrate of lower alkyl amine, di-lower alkyl amine or tri-lower alkyl amine)); two R<1><3> are independently primary or secondary C1-6 alkyl; or two R<1><3> together form -(CH2)2- or -(CH2)3; R<1><7> and R<1><8> are independently hydrogen or C1-3 alkyl; and R<5> is hydrogen, C1-6 alkyl, C2-3 alkenyl, C3-6 cycloalkyl, (wherein R<9> is a hydrogen atom, C1-4 alkyl, C1-3 alkoxy, fluoro, chloro, bromo or trifluoromethyl), phenyl-(CH2)m- (wherein m is 1,2 or 3), -(CH2)nCH(CH3)-phenyl or phenyl-(CH2)nCH(CH3)- (wherein n is 0,1 or 2).