发明名称 |
Method for protein-liposome coupling |
摘要 |
This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subsequently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates.
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申请公布号 |
US5399331(A) |
申请公布日期 |
1995.03.21 |
申请号 |
US19920946806 |
申请日期 |
1992.09.17 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
LOUGHREY, HELEN C.;CULLIS, PIETER R.;BALLY, MARCEL B.;CHOI, LEWIS S. |
分类号 |
A61K9/127;A61K38/00;A61K47/48;C07D207/40;C07D207/404;C07D207/46;(IPC1-7):A61K37/22 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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