IONTOPHORETIC DELIVERY OF AN ANTIMIGRAINE DRUG

摘要

The present invention relates to the iontophoretic delivery to a patient, more in particular to a migraine patient, of a compound of formula (I) as shown. The invention also relates to a device for the iontophoretic delivery of a compound of formula (I), as well as to a composition containing a compound of formula (I), which can be applied in a device for iontophoretic delivery. Said compounds are benzopyranalkylaminoalkyl substituted guanidines having formula (I), the pharmaceutically acceptable acid addition salts thereof, and the sterochemically isomeric forms thereof, wherein R<1> is hydrogen or C1-6alkyl; R<2> is hydrogen, C1-6alkyl, C3-6alkenyl or C3-6alkynyl, R<3> is hydrogen or C1-6alkyl; or R<2> and R<3> taken together form a bivalent radical of formula -(CH2)m- wherein m is 4 or 5; or R<1> and R<2> taken together form a bivalent radical of formula -CH=CH- or of formula -(CH2)n-, wherein n is 2, 3 or 4; or R<3> may represent a bond when R<1> and R<2> taken together form a bivalent radical of formula -CH=CH-CH=; R<4> and R<5> each independently are hydrogen or C1-6alkyl; Alk<1> is a bivalent C1-3alkanediyl radical; Alk<2> is bivalent C2-15alkanediyl radical; and R<6> and R<7> each independently are hydrogen, halo, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, hydroxy, C1-6alkyloxy or cyano.