| 摘要 |
The human GLP-1 receptor is cloned and used in an in vitro assay to screen for compounds that specifically bind to the human GLP-1 receptor, including compounds effective to reduce symptoms of diabetes. The invention includes the assay, the cloned human receptor used in the assay, an isolated human GLP-1 receptor free of other human proteins, and compounds identified through the use of this novel, cloned receptor, which selectively bind the human GLP-1 receptor.
|
| 申请人 |
MERCK & CO., INC.;GRAZIANO, MICHAEL, P.;BORKOWSKI, DOREEN, A.;CHICCHI, GARY, G.;HEY, PATRICIA, J.;STRADER, CATHERINE, D. |
发明人 |
GRAZIANO, MICHAEL, P.;BORKOWSKI, DOREEN, A.;CHICCHI, GARY, G.;HEY, PATRICIA, J.;STRADER, CATHERINE, D. |
